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BDBM382123 6-(4-(2,4-difluorophenoxy)piperidin-1-yl)-5-(isopropylamino)-3-morpholinopyrazine-2-carbonitrile::US10000468, Example 32::US10273225, Example 32

SMILES: CC(C)Nc1nc(N2CCOCC2)c(nc1N1CCC(CC1)Oc1ccc(F)cc1F)C#N

InChI Key: InChIKey=UUPPUNREICFVIO-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB:
Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 382123   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM382123
PNG
(6-(4-(2,4-difluorophenoxy)piperidin-1-yl)-5-(isopr...)
Show SMILES CC(C)Nc1nc(N2CCOCC2)c(nc1N1CCC(CC1)Oc1ccc(F)cc1F)C#N
Show InChI InChI=1S/C23H28F2N6O2/c1-15(2)27-21-23(28-19(14-26)22(29-21)31-9-11-32-12-10-31)30-7-5-17(6-8-30)33-20-4-3-16(24)13-18(20)25/h3-4,13,15,17H,5-12H2,1-2H3,(H,27,29)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.35E+4n/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10273225 (2019)


BindingDB Entry DOI: 10.7270/Q24X5B3J
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM382123
PNG
(6-(4-(2,4-difluorophenoxy)piperidin-1-yl)-5-(isopr...)
Show SMILES CC(C)Nc1nc(N2CCOCC2)c(nc1N1CCC(CC1)Oc1ccc(F)cc1F)C#N
Show InChI InChI=1S/C23H28F2N6O2/c1-15(2)27-21-23(28-19(14-26)22(29-21)31-9-11-32-12-10-31)30-7-5-17(6-8-30)33-20-4-3-16(24)13-18(20)25/h3-4,13,15,17H,5-12H2,1-2H3,(H,27,29)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.35E+4n/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10000468 (2018)


BindingDB Entry DOI: 10.7270/Q23R0W71
More data for this
Ligand-Target Pair