BDBM382356 US10273259, Example 69::US10711020, Example 69
SMILES OC1(CCS(=O)(=O)CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1
InChI Key InChIKey=ONXFNBOZJKXCNC-ZJSXRUAMSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 26 hits for monomerid = 382356
Affinity DataIC50: 36nMAssay Description:The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...More data for this Ligand-Target Pair
Affinity DataEC50: 43nMAssay Description:Inverse agonist activity at RORgammat in human whole blood assessed as inhibition of anti-CD3/anti-CD28 monoclonal antibodies-stimulated IL-17A produ...More data for this Ligand-Target Pair
Affinity DataEC50: 13nMAssay Description:Inverse agonist activity at RORgammat in mouse cells by mTh17 assayMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at RORalpha (unknown origin) by Gal4-Luc reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at RORbeta (unknown origin) by Gal4-Luc reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: >7.50E+3nMAssay Description:Agonist activity at LXRbeta (unknown origin) by Gal4-Luc reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of recombinant CYP1A2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of recombinant CYP2C8 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of recombinant CYP2D6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of recombinant CYP3A4 (unknown origin) using BFC substrateMore data for this Ligand-Target Pair
Affinity DataEC50: 24nMAssay Description:Inverse agonist activity at full length human RORgammat expressed in human Jurkat cells assessed as inhibition of constitutive receptor activity incu...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataIC50: >4.00E+4nMAssay Description:Activity at PXR (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Activity at LXRbeta (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: >7.50E+3nMAssay Description:Agonist activity at LXRalpha (unknown origin) by Gal4-Luc reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Activity at RORbeta (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Activity at LXRalpha (unknown origin)More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at PXR (unknown origin) by Gal4-Luc reporter gene assay)More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of recombinant CYP2C19 (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 440nMAssay Description:Inverse agonist activity at RORgammat in CD3/CD28/IL-1/IL-23-stimulated C57/B6 mouse whole blood assessed as reduction in IL17A production incubated ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Activity at RORalpha (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 43nMAssay Description:Inverse agonist activity at RORgammat in CD3 and CD28-stimulated human whole blood assessed as reduction in IL17A production incubated for 1 hr befor...More data for this Ligand-Target Pair
Affinity DataEC50: 24nMAssay Description:Inverse agonist activity at human Gal4-fused RORgammat expressed in human Jurkat cells assessed as inhibition of constitutive receptor activity measu...More data for this Ligand-Target Pair
Affinity DataEC50: 43nMAssay Description:Inverse agonist activity at RORgammat in CD3 and CD28-stimulated human whole blood assessed as suppression of IL17 incubated for 1 hr before CD3 and ...More data for this Ligand-Target Pair
Affinity DataEC50: 24nMAssay Description:Inverse agonist activity at human Gal4-fused RORgammat expressed in human Jurkat cells luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...More data for this Ligand-Target Pair