BDBM384177 8-(3-(2,3-Dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-2-fluoro-8-azaspiro[4.5]decan-1-amine::US10280171, Example 64A

SMILES NC1[C@H](F)CCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 384177   

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
The University Of Texas System

US Patent
LigandPNGBDBM384177(8-(3-(2,3-Dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazi...)
Affinity DataIC50:  34nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Homo sapiens (Human))
The University Of Texas System

US Patent
LigandPNGBDBM384177(8-(3-(2,3-Dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazi...)
Affinity DataIC50:  98nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent