BDBM384569 4-({cis or trans-4-[(3R or S)-3- (trifluoromethyl)piperidin- 1- yl]cyclohexyl}amino) quinazoline-6-carbonitrile::US9932350, 3-3::US9932350, 3-4::US9932350, 3-5

SMILES FC(F)(F)C1CCCN(C1)C1CCC(CC1)Nc1ncnc2ccc(cc12)C#N

InChI Key InChIKey=ALTVKDPSXAFXEM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 384569   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384569(4-({cis or trans-4-[(3R or S)-3- (trifluoromethyl)...)
Affinity DataIC50:  7nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384569(4-({cis or trans-4-[(3R or S)-3- (trifluoromethyl)...)
Affinity DataIC50:  908nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384569(4-({cis or trans-4-[(3R or S)-3- (trifluoromethyl)...)
Affinity DataIC50:  503nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent