BDBM384861 N-{(1R)-1-[4-(1,1-difluoroethyl)-3- fluorophenyl]-2-methylpropyl}-2- (dimethylamino)-6-oxo-1,6- dihydropyrimidine-4-carboxamide::US10285989, Example 77

SMILES CC(C)[C@@H](NC(=O)c1cc(=O)[nH]c(n1)N(C)C)c1ccc(c(F)c1)C(C)(F)F

InChI Key

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 384861   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384861(N-{(1R)-1-[4-(1,1-difluoroethyl)-3- fluorophenyl]-...)
Affinity DataKi:  0.190nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384861(N-{(1R)-1-[4-(1,1-difluoroethyl)-3- fluorophenyl]-...)
Affinity DataKi:  0.210nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent