BDBM385410 4-((R or S)-6-(azetidin-3- yl(methyl)carbamoyl)- 1-(2-chloro-6- cyclopropylbenzoyl)- 4,5,6,7-tetrahydro-1H- indazol-3-yl)cyclohex- 3-ene-1-carboxylic acid::US10287272, Example 2S::US10689369, Example 2S

SMILES CN(C1CNC1)C(=O)C1CCc2c(C1)n(nc2C1=CCC(CC1)C(O)=O)C(=O)c1c(Cl)cccc1C1CC1

InChI Key InChIKey=ITFZAHIWDBUXFO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 385410   

TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385410(4-((R or S)-6-(azetidin-3- yl(methyl)carbamoyl)- 1...)
Affinity DataIC50:  18nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385410(4-((R or S)-6-(azetidin-3- yl(methyl)carbamoyl)- 1...)
Affinity DataIC50:  18nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent