BDBM385416 4-((6R or S)-1-(2- chloro-6- cyclopropylbenzoyl)-6- (1-methyloctahydropyrrolo [3,4-b]pyrrole-5- carbonyl)-4,5,6,7- tetrahydro-1H-indazol- 3-yl)cyclohex-3-ene-1- carboxylic acid::US10287272, Example 2Y::US10689369, Example 2Y
SMILES CN1CCC2CN(CC12)C(=O)C1CCc2c(C1)n(nc2C1=CCC(CC1)C(O)=O)C(=O)c1c(Cl)cccc1C1CC1
InChI Key InChIKey=HXJPEKJDCANHSU-UHFFFAOYSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 385416
Affinity DataIC50: 61nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...More data for this Ligand-Target Pair
Affinity DataIC50: 61nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair