BDBM385450 4-((R or S)-1-(2- chloro-6-cyclopropyl- 3-fluorobenzoyl)-6- ((R)-3- (dimethylamino) pyrrolidine-1-carbonyl)- 4,5,6,7-tetrahydro- 1H-indazol-3- yl)cyclohex-3-ene-1- carboxylic acid::US10287272, Example 4A::US10689369, Example 4A

SMILES CN(C)[C@@H]1CCN(C1)C(=O)C1CCc2c(C1)n(nc2C1=CCC(CC1)C(O)=O)C(=O)c1c(ccc(F)c1Cl)C1CC1

InChI Key InChIKey=VQGAWDKCMYVYOK-XVAXZDLZSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 385450   

TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385450(4-((R or S)-1-(2- chloro-6-cyclopropyl- 3-fluorobe...)
Affinity DataIC50:  4nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385450(4-((R or S)-1-(2- chloro-6-cyclopropyl- 3-fluorobe...)
Affinity DataIC50:  4nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent