BDBM385469 (R or S)-4-((R or S)-1- (2-chloro-6-(1- (trifluoromethyl) cyclopropyl)benzoyl)-6-((3- (dimethylamino)-2,2- difluoropropyl)carbamoyl)- 4,5,6,7-tetrahydro- 1H-indazol-3- yl)cyclohex-3-ene-1- carboxylic acid::US10287272, Example 5N::US10689369, Example 5N

SMILES CN(C)CC(F)(F)CNC(=O)C1CCc2c(C1)n(nc2C1=CCC(CC1)C(O)=O)C(=O)c1c(Cl)cccc1C1(CC1)C(F)(F)F

InChI Key InChIKey=UDBLXJOTBXIIJR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 385469   

TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385469((R or S)-4-((R or S)-1- (2-chloro-6-(1- (trifluoro...)
Affinity DataIC50:  49nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385469((R or S)-4-((R or S)-1- (2-chloro-6-(1- (trifluoro...)
Affinity DataIC50:  49nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent