BDBM385536 (1R,6S or 1S,6R)-4- ((S or R)-1-(2-chloro- 6-(1- (trifluoromethyl)cyclo- propyl)benzoyl)-6- (4- hydroxypiperidine-1- carbonyl)-4,5,6,7- tetrahydro-1H- indazol-3-yl)-6- methylcyclohex-3- ene-1-carboxylic acid::US10287272, Example 17H::US10689369, Example 17H

SMILES C[C@H]1CC(=CC[C@H]1C(O)=O)c1nn(C(=O)c2c(Cl)cccc2C2(CC2)C(F)(F)F)c2CC(CCc12)C(=O)N1CCC(O)CC1

InChI Key InChIKey=ZOXHAJWMESADHM-PRZWFREHSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 385536   

TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385536((1R,6S or 1S,6R)-4- ((S or R)-1-(2-chloro- 6-(1- (...)
Affinity DataIC50:  2nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385536((1R,6S or 1S,6R)-4- ((S or R)-1-(2-chloro- 6-(1- (...)
Affinity DataIC50:  2nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent