BDBM385976 US10287293, Example 25

SMILES CC(c1nn(C)c2c1nc(C)[nH]c2=O)c1ccc(cc1)C(F)(F)F

InChI Key

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 385976   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385976(US10287293, Example 25)
Affinity DataKi:  60.9nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385976(US10287293, Example 25)
Affinity DataKi:  70nMAssay Description:Inhibition of human PDE2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385976(US10287293, Example 25)
Affinity DataKi:  70.3nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent