BDBM386088 (2R,3S)-N-ethyl-3- ((methylsulfonyl)amino)-2-(((cis-4- phenylcyclohexyl)oxy)methyl)- piperidine-1-carboxamide::US10287305, Example 30::US10508083, Example 30::US11292766, Example 30

SMILES CCNC(=O)N1CCC[C@H](NS(C)(=O)=O)[C@@H]1CO[C@H]1CC[C@H](CC1)c1ccccc1

InChI Key InChIKey=GCSPLXQGOXYDRB-WOZUAGRISA-N

Data  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 386088   

TargetOrexin receptor type 2(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386088((2R,3S)-N-ethyl-3- ((methylsulfonyl)amino)-2-(((ci...)
Affinity DataEC50:  0.110nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386088((2R,3S)-N-ethyl-3- ((methylsulfonyl)amino)-2-(((ci...)
Affinity DataEC50:  0.110nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM386088((2R,3S)-N-ethyl-3- ((methylsulfonyl)amino)-2-(((ci...)
Affinity DataEC50: >1.40E+4nMAssay Description:Agonist activity at human OX1R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386088((2R,3S)-N-ethyl-3- ((methylsulfonyl)amino)-2-(((ci...)
Affinity DataEC50:  0.290nMAssay Description:Agonist activity at human OX2R expressed in CHO-K1 cells by FLIPR calcium flux assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386088((2R,3S)-N-ethyl-3- ((methylsulfonyl)amino)-2-(((ci...)
Affinity DataEC50:  11nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent