BDBM387032 2-(4-fluorophenyl)-N-[5-[[(3R)-1-(6-fluoropyridazin-3-yl)pyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]-2-methoxy-acetamide::US9938265, Example 19::US9938265, Example 20

SMILES COC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(F)nn2)s1)c1ccc(F)cc1

InChI Key InChIKey=FRJXKZOHYZWERA-JBZHPUCOSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 387032   

TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387032(2-(4-fluorophenyl)-N-[5-[[(3R)-1-(6-fluoropyridazi...)
Affinity DataIC50:  323nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387032(2-(4-fluorophenyl)-N-[5-[[(3R)-1-(6-fluoropyridazi...)
Affinity DataIC50:  55.7nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent