BDBM387059 US9938272, Example 8a::US9938272, Example 8b
SMILES COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C3CCN(CC3)C3CCNC3=O)C(=O)c12
InChI Key InChIKey=MTLRBJOPNITTML-UHFFFAOYSA-N
Data 7 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 387059
Affinity DataKi: <10nMAssay Description:Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...More data for this Ligand-Target Pair
Affinity DataKi: 30nMAssay Description:Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...More data for this Ligand-Target Pair
Affinity DataKi: 30nMAssay Description:Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...More data for this Ligand-Target Pair
TargetCoagulation factor V/Coagulation factor X/Serine/threonine-protein kinase BRSK2(Homo sapiens (Human))
North China Pharmaceutical
US Patent
North China Pharmaceutical
US Patent
Affinity DataKi: 30nMAssay Description:Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...More data for this Ligand-Target Pair
Affinity DataKi: 525nMAssay Description:Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nMAssay Description:Thrombin: In the assay for measuring the inhibition of human thrombin activity buffer (10 mM HEPES buffer, pH 7.4, 2 mM CaCl2) is used. The IC50 is m...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nMAssay Description:Trypsin: In the assay for measuring the inhibition of human trypsin activity buffer (50 mM Tris, pH 8.2, and 20 mM CaCl2) is used. The IC50 is measur...More data for this Ligand-Target Pair