BDBM387180 5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)-N-ethylhexahydrocyclopenta[c]pyrrole-2(1H)-carboxamide::US9938257, Example 18

SMILES CCNC(=O)N1CC2CC(CC2C1)Nc1nc(Nc2cnn(C)c2)ncc1Cl

InChI Key InChIKey=YHTMTLWBCNPEPE-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 387180   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM387180(5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)py...)
Affinity DataIC50:  12nMAssay Description:JAK1:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAurora kinase A(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM387180(5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)py...)
Affinity DataIC50:  11nMAssay Description:Aurora-A:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM387180(5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)py...)
Affinity DataIC50:  1.03E+3nMAssay Description:FLT3:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM387180(5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)py...)
Affinity DataIC50:  2nMAssay Description:Aurora-B:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Calitor Sciences

US Patent
LigandPNGBDBM387180(5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)py...)
Affinity DataIC50:  142nMAssay Description:JAK2:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent