BDBM387337 7-methoxy-N-{2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}quinolin-4-amine::US10292985, Example 20

SMILES COc1ccc2c(Nc3nc(nn4cccc34)-c3cccc(n3)C(F)(F)F)ccnc2c1

InChI Key InChIKey=NPWSJRBJNIOWDX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 387337   

TargetTGF-beta receptor type-2(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM387337(7-methoxy-N-{2-[6-(trifluoromethyl)pyridin-2-yl]py...)
Affinity DataIC50: >1.50E+4nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM387337(7-methoxy-N-{2-[6-(trifluoromethyl)pyridin-2-yl]py...)
Affinity DataIC50:  4.20nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent