BDBM388681 (S)-4-(1-(5-amino-4H-1,2,4-triazol-3-yl)piperidin-4-yl)-3-(4-chlorobenzyl)thiomorpholine 1,1-dioxide ::US10538508, Example 43::US9944624, Ex. 43

SMILES Nc1nnc([nH]1)N1CCC(CC1)N1CCS(=O)(=O)CC1Cc1ccc(Cl)cc1

InChI Key

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 388681   

TargetAcidic mammalian chitinase(Homo sapiens (Human))
Oncoarendi Therapeutics

US Patent
LigandPNGBDBM388681((S)-4-(1-(5-amino-4H-1,2,4-triazol-3-yl)piperidin-...)
Affinity DataIC50:  550nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetChitotriosidase-1(Homo sapiens (Human))
Oncoarendi Therapeutics

US Patent
LigandPNGBDBM388681((S)-4-(1-(5-amino-4H-1,2,4-triazol-3-yl)piperidin-...)
Affinity DataIC50:  5.50E+3nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcidic mammalian chitinase(Homo sapiens (Human))
Oncoarendi Therapeutics

US Patent
LigandPNGBDBM388681((S)-4-(1-(5-amino-4H-1,2,4-triazol-3-yl)piperidin-...)
Affinity DataIC50:  550nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetChitotriosidase-1(Homo sapiens (Human))
Oncoarendi Therapeutics

US Patent
LigandPNGBDBM388681((S)-4-(1-(5-amino-4H-1,2,4-triazol-3-yl)piperidin-...)
Affinity DataIC50:  5.50E+3nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent