BDBM389651 (E)-6-(4-(4-(dimethylamino)but-2-enoyl)piperazin-1-yl)-2-(4-phenoxyphenyl)nicotinamide::US11345695, Example 25::US11840513, Example 25::US9951056, Example 25
SMILES CN(C)C\C=C\C(=O)N1CCN(CC1)c1ccc(C(N)=O)c(n1)-c1ccc(Oc2ccccc2)cc1
InChI Key InChIKey=HKODXZQCALAKRP-RMKNXTFCSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 389651
Affinity DataIC50: <500nMAssay Description:1× and 2× assay buffer were made at first. BTK kinase was diluted with 1× assay buffer but substrate was diluted with 2× assay buffer. 1 ul of dilute...More data for this Ligand-Target Pair
Affinity DataIC50: <500nMAssay Description:The activity of the Examples and Analogs described herein, as inhibitors of BTK are demonstrated and confirmed by pharmacological in vitro assays. Ac...More data for this Ligand-Target Pair
Affinity DataIC50: <500nMAssay Description:1x and 2x assay buffer were made at first. BTK kinase was diluted with 1× assay buffer but substrate was diluted with 2× assay buffer. 1 ul of dilute...More data for this Ligand-Target Pair
Affinity DataIC50: <500nMAssay Description:1× and 2× assay buffer were made at first. BTK kinase was diluted with 1× assay buffer but substrate was diluted with 2× assay buffer. 1 ul of dilute...More data for this Ligand-Target Pair