BDBM389656 1-(1-(4-(dimethylamino)but-2-enoyl)pyrrolidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide::US11840513, Example 34::US9951056, Example 34

SMILES CN(C)C\C=C\C(=O)N1CCC(C1)n1cc(C(N)=O)c(n1)-c1ccc(Oc2ccccc2)cc1

InChI Key InChIKey=AEDIDQOBLIIZIJ-RMKNXTFCSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 389656   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Guangzhou Innocare Pharma Tech

US Patent
LigandPNGBDBM389656(1-(1-(4-(dimethylamino)but-2-enoyl)pyrrolidin-3-yl...)
Affinity DataIC50: <500nMAssay Description:1× and 2× assay buffer were made at first. BTK kinase was diluted with 1× assay buffer but substrate was diluted with 2× assay buffer. 1 ul of dilute...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Guangzhou Innocare Pharma Tech

US Patent
LigandPNGBDBM389656(1-(1-(4-(dimethylamino)but-2-enoyl)pyrrolidin-3-yl...)
Affinity DataIC50: <500nMAssay Description:The activity of the Examples and Analogs described herein, as inhibitors of BTK are demonstrated and confirmed by pharmacological in vitro assays. Ac...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Guangzhou Innocare Pharma Tech

US Patent
LigandPNGBDBM389656(1-(1-(4-(dimethylamino)but-2-enoyl)pyrrolidin-3-yl...)
Affinity DataIC50: <500nMAssay Description:1× and 2× assay buffer were made at first. BTK kinase was diluted with 1× assay buffer but substrate was diluted with 2× assay buffer. 1 ul of dilute...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent