BDBM391028 (2S,5S)-tert-butyl 5- (cyanomethyl)-5-(3-((4- (cyclopropylsulfonyl) phenyl)amino)-4-oxo- 4,5-dihydro-1H-pyrazolo [4,3-c]pyridin-1-yl) tetrahydro-2H-pyran-2- carboxylate (from I-14-1A)::US9957264, Example 5-236::US9957264, Example 5-99
SMILES CC(C)(C)OC(=O)[C@@H]1CC[C@](CC#N)(CO1)n1nc(Nc2ccc(cc2)S(=O)(=O)C2CC2)c2c1cc[nH]c2=O
InChI Key
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 391028
Affinity DataIC50: 0.0500nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.25nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.120nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.140nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair