BDBM391185 2-((3R,4R or 3S,4S)-4-(3-((2- (tert-butyl)-1,1-dioxido-2,3- dihydrobenzo[d]isothiazol-5- yl)amino)-4-oxo-4,5- dihydro-1H-pyrazolo[4,3- c]pyridin-1-yl)-3- fluorotetrahydro-2H-pyran- 4-yl)acetonitrile (from racemic cis I-22) (Chiral HPLC on freee pyridone using AD-H; Hexanes (0.1% DEA):EtOH (0.1% DEA) = 50:50, Tr = 26 minutes)::US9957264, Example 5-256

SMILES CC(C)(C)N1Cc2cc(Nc3nn(c4cc[nH]c(=O)c34)[C@]3(CC#N)CCOC[C@@H]3F)ccc2S1(=O)=O

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 391185   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391185(2-((3R,4R or 3S,4S)-4-(3-((2- (tert-butyl)-1,1-dio...)
Affinity DataIC50:  0.0600nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391185(2-((3R,4R or 3S,4S)-4-(3-((2- (tert-butyl)-1,1-dio...)
Affinity DataIC50:  0.0400nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent