BDBM392346 US10301278, Example 27b

SMILES C[C@@]1(CN)CCN(C[C@@H]1O)c1cnc(Sc2cccc(Cl)c2Cl)c(N)n1

InChI Key InChIKey=JFABKFBJKXNMAH-SJCJKPOMSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 392346   

TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM392346(US10301278, Example 27b)
Affinity DataIC50:  377nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent