BDBM393336 5-(3-Fluoro-4-(((1S,3S)-3-isothiocyanatocyclobutoxy)methyl)phenyl)benzo[d][1,3]dioxole::US9963444, Example 39

SMILES Fc1cc(ccc1CO[C@H]1C[C@H](C1)N=C=S)-c1ccc2OCOc2c1

InChI Key InChIKey=KQGLLRHWAILNOI-IYBDPMFKSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 393336   

TargetN-acylethanolamine-hydrolyzing acid amidase(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM393336(5-(3-Fluoro-4-(((1S,3S)-3-isothiocyanatocyclobutox...)
Affinity DataIC50:  8.80nMAssay Description:Inhibition of human NAAA using N-(4-methyl coumarin)-palmitamide as fluorogenic substrate preincubated for 90 mins followed by substrate addition by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetN-acylethanolamine-hydrolyzing acid amidase(Homo sapiens (Human))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM393336(5-(3-Fluoro-4-(((1S,3S)-3-isothiocyanatocyclobutox...)
Affinity DataIC50:  55nMAssay Description:In order to have an assay method more conducive to high-throughput screening than those published for measuring the NAE hydrolyzing activity of NAAA,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent