BDBM393784 US10597367, Example 73::US9969726, Example 73

SMILES OC(=O)c1cc(ccc1F)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccc(nc1)C(F)(F)F

InChI Key InChIKey=KJZLSFUOPRRFTK-UHFFFAOYSA-N

Data  8 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 393784   

TargetMetabotropic glutamate receptor 2(Rattus norvegicus)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM393784(US10597367, Example 73 | US9969726, Example 73)
Affinity DataEC50:  820nMAssay Description:Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 2(Rattus norvegicus)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM393784(US10597367, Example 73 | US9969726, Example 73)
Affinity DataEC50:  170nMAssay Description:Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM393784(US10597367, Example 73 | US9969726, Example 73)
Affinity DataEC50:  1.18E+3nMAssay Description:Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM393784(US10597367, Example 73 | US9969726, Example 73)
Affinity DataEC50:  780nMAssay Description:Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 2(Rattus norvegicus)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM393784(US10597367, Example 73 | US9969726, Example 73)
Affinity DataEC50:  820nMAssay Description:Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 2(Rattus norvegicus)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM393784(US10597367, Example 73 | US9969726, Example 73)
Affinity DataEC50:  170nMAssay Description:Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM393784(US10597367, Example 73 | US9969726, Example 73)
Affinity DataEC50:  1.18E+3nMAssay Description:Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM393784(US10597367, Example 73 | US9969726, Example 73)
Affinity DataEC50:  780nMAssay Description:Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent