BDBM393925 US9969749, Example 1-19::trans-N,N-dimethyl-N'- {6-[1-(pyridin-4- ylmethyl)-1H-pyrazol-4- yl]quinazolin-4- yl}cyclohexane-1,4- diamine

SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C(\C=N)=C\NCc1ccncc1

InChI Key InChIKey=QZTHKQIVLWIDMS-IPQSIERPSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 393925   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM393925(US9969749, Example 1-19 | trans-N,N-dimethyl-N'- {...)
Affinity DataIC50:  358nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent