BDBM394030 4-(4-{[trans-4- (morpholin-4- yl)cyclohexyl]amino} quinazolin-6-yl)thiophene- 3-carbonitrile::US9969749, Example 2-18

SMILES N#Cc1cscc1-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1

InChI Key InChIKey=KKTAOHPLXUEIPY-WGSAOQKQSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 394030   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM394030(4-(4-{[trans-4- (morpholin-4- yl)cyclohexyl]amino}...)
Affinity DataIC50:  52nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent