BDBM394078 US9969749, Example 5-28::cyclopropyl{4-[trans-4- ({6-[6-fluoro-5- (methylamino)pyridin-3- yl]quinazolin-4- yl}amino)cyclohexyl] piperazin-1-yl}methanone

SMILES CNc1cc(cnc1F)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCN(CC3)C(=O)C3CC3)c2c1

InChI Key InChIKey=WIBWUPMFIHPTAC-HZCBDIJESA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 394078   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM394078(US9969749, Example 5-28 | cyclopropyl{4-[trans-4- ...)
Affinity DataIC50:  1nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent