BDBM394123 US9975861, 3::US9975861, 4::US9975861, 5
SMILES CCNC1=NC(NC(=O)N1)c1ccc(F)cc1
InChI Key InChIKey=XWRLROSVVBGPPA-UHFFFAOYSA-N
Data 8 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 394123
Affinity DataIC50: 1.61E+4nMAssay Description:β-secretase (BACE-1, Sigma-Aldrich) inhibition studies were performed by employing a peptide mimicking APP sequence as substrate (Methoxycoumari...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Fondazione Istituto Itaiano Di Tecnologia
US Patent
Fondazione Istituto Itaiano Di Tecnologia
US Patent
Affinity DataIC50: 7.11E+3nMAssay Description:Human recombinant GSK-3β was purchased from Millipore (Millipore Iberica S.A.U.) The prephosphorylated polypeptide substrate was purchased from ...More data for this Ligand-Target Pair
Affinity DataIC50: 8.13E+3nMAssay Description:β-secretase (BACE-1, Sigma-Aldrich) inhibition studies were performed by employing a peptide mimicking APP sequence as substrate (Methoxycoumari...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Fondazione Istituto Itaiano Di Tecnologia
US Patent
Fondazione Istituto Itaiano Di Tecnologia
US Patent
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of human recombinant GSK3beta using prephosphorylated polypeptide GSM as substrate incubated for 30 mins in presence of ATP by Kinase-Glo ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.26E+4nMAssay Description:β-secretase (BACE-1, Sigma-Aldrich) inhibition studies were performed by employing a peptide mimicking APP sequence as substrate (Methoxycoumari...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Fondazione Istituto Itaiano Di Tecnologia
US Patent
Fondazione Istituto Itaiano Di Tecnologia
US Patent
Affinity DataIC50: 1.57E+4nMAssay Description:Human recombinant GSK-3β was purchased from Millipore (Millipore Iberica S.A.U.) The prephosphorylated polypeptide substrate was purchased from ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of C-terminal His-tagged recombinant human BACE-1 expressed in mouse NSO cells using methoxy coumarin Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Fondazione Istituto Itaiano Di Tecnologia
US Patent
Fondazione Istituto Itaiano Di Tecnologia
US Patent
Affinity DataIC50: 1.26E+4nMAssay Description:Human recombinant GSK-3β was purchased from Millipore (Millipore Iberica S.A.U.) The prephosphorylated polypeptide substrate was purchased from ...More data for this Ligand-Target Pair