BDBM394158 3-[(4-{3-[(1S)- 1-{5-[5-chloro- 2-(1H- tetrazol-1- yl)phenyl]-1- oxidopyridin- 2-yl}-2- phenylethyl] phenyl} piperidin- 1- yl)carbonyl] cyclobutanone::US9975874, Example 32

SMILES Clc1ccc(c(c1)-c1ccc([nH+]c1)[C@@H](Cc1ccccc1)c1cccc(c1)C1CCN(CC1)C(=O)C1CC(=O)C1)-n1cnnn1

InChI Key InChIKey=QUSNISKZXOJQDZ-YTTGMZPUSA-O

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 394158   

TargetPlasma kallikrein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM394158(3-[(4-{3-[(1S)- 1-{5-[5-chloro- 2-(1H- tetrazol-1-...)
Affinity DataIC50:  324nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Kallikrein can be determined using a relevant purified serine protease, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM394158(3-[(4-{3-[(1S)- 1-{5-[5-chloro- 2-(1H- tetrazol-1-...)
Affinity DataIC50:  11.1nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent