BDBM394175 4-{3-[(1S)-1- {5-[5-chloro-2- (1H-tetrazol- 1-yl)phenyl]- 1- oxidopyridin- 2-yl}-2- phenylethyl] phenyl}-N- (tetrahydrofuran- 3- yl)piperidine- 1- carboxamide::US9975874, Example 49

SMILES [O-][n+]1cc(ccc1[C@@H](Cc1ccccc1)c1cccc(c1)C1CCN(CC1)C(=O)NC1CCOC1)-c1cc(Cl)ccc1-n1cnnn1

InChI Key InChIKey=IVLHGJVYHNUUFI-JYUUXGOASA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 394175   

TargetPlasma kallikrein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM394175(4-{3-[(1S)-1- {5-[5-chloro-2- (1H-tetrazol- 1-yl)...)
Affinity DataIC50:  414nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Kallikrein can be determined using a relevant purified serine protease, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM394175(4-{3-[(1S)-1- {5-[5-chloro-2- (1H-tetrazol- 1-yl)...)
Affinity DataIC50:  6.89nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent