BDBM394366 N-[3-[2-(difluoromethoxy)-5-[4- (dimethylcarbamoyl)phenoxy]phenyl]- 1-[2-(dimethylamino)-2-oxo- ethyl]pyrazol-4-yl]pyrazolo[1,5- a]pyrimidine-3-carboxamide::US10307426, Example 8

SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Oc2ccc(cc2)C(=O)N(C)C)ccc1OC(F)F

InChI Key InChIKey=YXXSQLNDBLHSPI-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 394366   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM394366(N-[3-[2-(difluoromethoxy)-5-[4- (dimethylcarbamoyl...)
Affinity DataKi:  0.830nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM394366(N-[3-[2-(difluoromethoxy)-5-[4- (dimethylcarbamoyl...)
Affinity DataKi:  1.81nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent