BDBM394376 N-(3-(2-(difluoromethoxy)-5-(3-(3- hydroxy-1-methylazetidin-3- yl)phenoxy)phenyl)-1-(2- (dimethylamino)-2-oxoethyl)-1H- pyrazol-4-yl)pyrazolo[1,5- a]pyrimidine-3-carboxamide::US10307426, Example 18

SMILES CN(C)C(=O)Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Oc2cccc(c2)C2(O)CN(C)C2)ccc1OC(F)F

InChI Key InChIKey=FRBLFLTVXJPVBV-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 394376   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM394376(N-(3-(2-(difluoromethoxy)-5-(3-(3- hydroxy-1-methy...)
Affinity DataKi:  1.56nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM394376(N-(3-(2-(difluoromethoxy)-5-(3-(3- hydroxy-1-methy...)
Affinity DataKi:  3.18nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent