BDBM394654 US10308615, Example 11::{2-[(pyrazin-2-ylmethyl)amino]pyrimidin-5-yl}[3-(trifluoromethyl)phenyl]methanone

SMILES FC(F)(F)c1cccc(c1)C(=O)c1cnc(NCc2cnccn2)nc1

InChI Key InChIKey=VMVMHPUREDQQQA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 394654   

TargetPantetheinase(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM394654(US10308615, Example 11 | {2-[(pyrazin-2-ylmethyl)a...)
Affinity DataIC50:  6.40nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPantetheinase(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM394654(US10308615, Example 11 | {2-[(pyrazin-2-ylmethyl)a...)
Affinity DataIC50: <6.20nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPantetheinase(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM394654(US10308615, Example 11 | {2-[(pyrazin-2-ylmethyl)a...)
Affinity DataIC50:  9nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent