BDBM395692 2-{3-[(3R,6R)-6-methyl-1-{[4-(2H- 1,2,3-triazol-2-yl)thiophen-3- yl]carbonyl}piperidin-3-yl]-1,2,4- thiadiazol-5-yl}propan-2-ol::US10308645, Example 31

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1cscc1-n1nccn1)c1nsc(n1)C(C)(C)O

InChI Key InChIKey=NCYQEDRSFBNUSC-VXGBXAGGSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 395692   

TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM395692(2-{3-[(3R,6R)-6-methyl-1-{[4-(2H- 1,2,3-triazol-2-...)
Affinity DataIC50:  1.00E+4nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM395692(2-{3-[(3R,6R)-6-methyl-1-{[4-(2H- 1,2,3-triazol-2-...)
Affinity DataIC50:  110nMAssay Description:The utility of the compounds in accordance with the present invention as orexin receptor OX1R and/or OX2R antagonists may be readily determined witho...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent