BDBM396040 US10308660, Example 142

SMILES C[C@@H]1OCC2(CCN(CC2)c2nc(N)c(-c3ccc(Oc4ccccc4)cc3)c(=O)n2C)[C@@H]1N

InChI Key InChIKey=KKHOYIXZBZGZIP-HTAPYJJXSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 396040   

TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM396040(US10308660, Example 142)
Affinity DataIC50:  27nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phosphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent