BDBM396849 US9981950, Example 56

SMILES Cc1nccn1Cc1cn(nn1)-c1ccc(Cl)c(c1)C(F)(F)F

InChI Key InChIKey=DRHMCKZRSIYNSH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 396849   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM396849(US9981950, Example 56)
Affinity DataIC50:  11.9nMAssay Description:Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM396849(US9981950, Example 56)
Affinity DataIC50:  11.9nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM396849(US9981950, Example 56)
Affinity DataIC50:  11.9nMAssay Description:Male Wistar rats (180 to 200 g) were killed by suffocation in a CO2 chamber for two minutes. Whole brains without cerebellum were removed and dissect...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent