BDBM398286 US10323016, Example 25

SMILES COc1ccc(cc1OC)N(C)c1cnc(SCc2c(F)cc(OCCC[N+]34CCN(CC3)CC4)cc2F)n1-c1ccc(F)cc1

InChI Key InChIKey=RMXSSKGSTYUERI-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 398286   

TargetG-protein coupled bile acid receptor 1(Mus musculus)
Universite De Lille 2 Droit Et Sante

US Patent
LigandPNGBDBM398286(US10323016, Example 25)
Affinity DataEC50:  10nMAssay Description:In the following tables TGR5 activation by compounds and subsequent increase in intracellular cAMP were evaluated using a luciferase reporter gene as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Universite De Lille 2 Droit Et Sante

US Patent
LigandPNGBDBM398286(US10323016, Example 25)
Affinity DataEC50:  240nMAssay Description:In the following tables TGR5 activation by compounds and subsequent increase in intracellular cAMP were evaluated using a luciferase reporter gene as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent