BDBM398503 (2R)-3-{[(cis-4-({4-[(Ethyl-5-methyl-1H-pyrazol-3-yl)amino]-1-methyl-1H-benzimidazol-6-yl}oxy)cyclohexyl]amino}-1,1,1-trifluoropropan-2-ol::US10323019, Example 7

SMILES CCn1nc(Nc2cc(O[C@@H]3CC[C@@H](CC3)NC[C@@H](O)C(F)(F)F)cc3n(C)cnc23)cc1C

InChI Key InChIKey=UIAURLWWOITKJN-GQIGUUNPSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 398503   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM398503((2R)-3-{[(cis-4-({4-[(Ethyl-5-methyl-1H-pyrazol-3-...)
Affinity DataIC50:  5.43nMAssay Description:The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM398503((2R)-3-{[(cis-4-({4-[(Ethyl-5-methyl-1H-pyrazol-3-...)
Affinity DataIC50:  6.16E+3nMAssay Description:The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM398503((2R)-3-{[(cis-4-({4-[(Ethyl-5-methyl-1H-pyrazol-3-...)
Affinity DataIC50:  901nMAssay Description:The JAK LanthaScreen Kinase Assay (Invitrogen) is used to determine the ability of test compounds to inhibit JAK1, JAK2, and JAK3 kinase activity. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent