BDBM400157 7-(2-((3,3-difluoro-1-(methylcarbamoyl)cyclobutyl)amino)-2-oxoacetyl)-N-(2-(difluoromethyl)-3-fluoropyridin-4-yl)-6-methyl-2,3-dihydro-1H-pyrrolizine-5-carboxamide::US10328053, Compound 147::US10874640, Compound 147::US20230270719, Compound 147

SMILES CNC(=O)C1(CC(F)(F)C1)NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccnc(C(F)F)c2F)n2CCCc12

InChI Key InChIKey=KYQJFMXGDILKQG-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 400157   

TargetSodium/bile acid cotransporter(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM400157(7-(2-((3,3-difluoro-1-(methylcarbamoyl)cyclobutyl)...)
Affinity DataEC50:  103nMAssay Description:A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/bile acid cotransporter(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM400157(7-(2-((3,3-difluoro-1-(methylcarbamoyl)cyclobutyl)...)
Affinity DataEC50:  103nMAssay Description:A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCapsid protein(Hepatitis B virus genotype C subtype ayr (isolate ...)
Gilead Sciences

US Patent
LigandPNGBDBM400157(7-(2-((3,3-difluoro-1-(methylcarbamoyl)cyclobutyl)...)
Affinity DataEC50:  103nMAssay Description:A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent