BDBM400280 US10695337, Example 35::US11285140, Example 35::US9999619, Example 36
SMILES: Fc1ccc(cc1F)C(=O)N1CCC(CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
InChI Key: InChIKey=UDQGRPPPPIRJIS-UHFFFAOYSA-N
Data: 6 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human)) | BDBM400280![]() (US10695337, Example 35 | US11285140, Example 35 | ...) | PDB GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Holdings Corporation US Patent | Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi... | US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human)) | BDBM400280![]() (US10695337, Example 35 | US11285140, Example 35 | ...) | PDB GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Holdings Corporation US Patent | Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi... | US Patent US9999619 (2018) BindingDB Entry DOI: 10.7270/Q2C82CNM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human)) | BDBM400280![]() (US10695337, Example 35 | US11285140, Example 35 | ...) | PDB GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation; Incyte Holdings Cororation US Patent | US Patent US11285140 (2022) | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK2 [828-1132] (Homo sapiens (Human)) | BDBM400280![]() (US10695337, Example 35 | US11285140, Example 35 | ...) | PDB MMDB KEGG DrugBank GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Holdings Corporation; Incyte Corporation US Patent | Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba... | US Patent US10695337 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human)) | BDBM400280![]() (US10695337, Example 35 | US11285140, Example 35 | ...) | PDB GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation; Incyte Holdings Cororation US Patent | Assay Description Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi... | US Patent US11285140 (2022) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 [837-1142] (Homo sapiens (Human)) | BDBM400280![]() (US10695337, Example 35 | US11285140, Example 35 | ...) | PDB GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Holdings Corporation; Incyte Corporation US Patent | Assay Description The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba... | US Patent US10695337 (2020) | |||||||||||
More data for this Ligand-Target Pair |