BDBM400703 US10000476, Compound I-62
SMILES Cc1cccn(CC2(NC(=O)NC2=O)c2cccc(c2)-c2cccnc2)c1=O
InChI Key InChIKey=LMJFGVCAZXWITE-UHFFFAOYSA-N
Data 9 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 400703
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Kaken Pharmaceutical
US Patent
Kaken Pharmaceutical
US Patent
Affinity DataIC50: <100nMAssay Description:The TACE inhibition test was carried out by measuring TACE activity in the presence and the absence of the test substance using the thus-obtained TAC...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:MMP-1: 180 μL (100 ng) of human MMP-1 (Calbiochem #444208) was mixed with 20 μL of 10 mM p-amino phenyl mercuric acetate (APMA), and activa...More data for this Ligand-Target Pair
Affinity DataIC50: 3.10E+4nMAssay Description:MMP-2: 90 μL (5 ng) of human MMP-2 (Calbiochem #444213) was mixed with 10 μL of 10 mM APMA, and activated by reacting at 37° C. for 1 hour....More data for this Ligand-Target Pair
Affinity DataIC50: 3.90E+4nMAssay Description:MMP-3: 90 μL (1.5 ng) of human MMP-3 (Calbiochem #444217) prepared with an assay buffer A was added to 90 μL of a 20 μM fluorescent su...More data for this Ligand-Target Pair
Affinity DataIC50: 4.50E+4nMAssay Description:MMP-17: 90 μL (5.8 ng) of human MMP-17 (Calbiochem #475940) prepared with an assay buffer A was added to 90 μL of a 20 μM fluorescent ...More data for this Ligand-Target Pair
Affinity DataIC50: 6.70E+4nMAssay Description:MMP-9: 90 μL (11 ng) of human MMP-9 (Calbiochem #444231) was mixed with 10 μL of 10 mM APMA, and activated by reacting at 37° C. for 2 hour...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:MMP-13: 90 μL (18 ng) of human MMP-13 (Calbiochem # CC068) or 90 μL (130 ng) of human MMP-13 (Calbiochem #444287) was mixed with 10 μL...More data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+4nMAssay Description:MMP-14: 90 μL (1.9 ng) of human MMP-14 (Calbiochem #475935) prepared with an assay buffer A was added to 90 μL of a 20 μM fluorescent ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:MMP-8: 90 μL (29 ng) of human MMP-8 (Calbiochem #444229) was mixed with 10 μL of 10 mM APMA, and activated by reacting at 37° C. for 1 hour...More data for this Ligand-Target Pair