BDBM400858 2-Amino-N-[5-(4-aminoazepan-1-yl)-1-methyl-1H-pyrazol-4-yl]-6-phenylthieno[3,2-b]pyridine-3-carboxamide::US10000507, Example 25

SMILES Cn1ncc(NC(=O)c2c(N)sc3cc(cnc23)-c2ccccc2)c1N1CCCC(N)CC1

InChI Key InChIKey=DZOSHIIOHUUQLL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 400858   

TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM400858(2-Amino-N-[5-(4-aminoazepan-1-yl)-1-methyl-1H-pyra...)
Affinity DataIC50: <10nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM400858(2-Amino-N-[5-(4-aminoazepan-1-yl)-1-methyl-1H-pyra...)
Affinity DataIC50: <10nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM400858(2-Amino-N-[5-(4-aminoazepan-1-yl)-1-methyl-1H-pyra...)
Affinity DataIC50:  55nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent