BDBM400889 2-amino-N-[5-(4-aminoazepan-1-yl)-1- methyl-1H-pyrazol-4-yl]-6- trifluoromethyl-furo[3,2-b]pyridine-3- carboxamide::US10000507, Example 56

SMILES Cn1ncc(NC(=O)c2c(N)oc3cc(cnc23)C(F)(F)F)c1N1CCCC(N)CC1

InChI Key InChIKey=HJSRCMVROIKXSP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 400889   

TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM400889(2-amino-N-[5-(4-aminoazepan-1-yl)-1- methyl-1H-pyr...)
Affinity DataIC50: <10nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM400889(2-amino-N-[5-(4-aminoazepan-1-yl)-1- methyl-1H-pyr...)
Affinity DataIC50: <10nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM400889(2-amino-N-[5-(4-aminoazepan-1-yl)-1- methyl-1H-pyr...)
Affinity DataIC50:  55nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent