BDBM401904 5-[5-(4-{[(1-cyclopropane-carbonyl-piperidin-4-ylmethyl)-amino]-methyl}-2-methoxy-phenyl)-1H-pyrazol-3-ylamino]-pyrazine-2-carbonitrile hydrochloride::US10010547, Example 12::US10973817, Example 12

SMILES COc1cc(CNCC2CCN(CC2)C(=O)C2CC2)ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1

InChI Key InChIKey=VQKAEOMCLUVCNZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 401904   

TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM401904(5-[5-(4-{[(1-cyclopropane-carbonyl-piperidin-4-ylm...)
Affinity DataIC50:  0.0340nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM401904(5-[5-(4-{[(1-cyclopropane-carbonyl-piperidin-4-ylm...)
Affinity DataIC50:  0.0340nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent