BDBM401963 US10010547, Example 71::US10973817, Example 71::methyl 5-[[5-[2-methoxy-4-(4-piperidyl)phenyl]-1H-pyrazol-3-yl]amino]pyrazine-2-carboxylatehydrochloride

SMILES COC(=O)c1cnc(Nc2cc([nH]n2)-c2ccc(cc2OC)C2CCNCC2)cn1

InChI Key InChIKey=UBZQSXGKLQMTRQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 401963   

TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM401963(US10010547, Example 71 | US10973817, Example 71 | ...)
Affinity DataIC50: >100nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM401963(US10010547, Example 71 | US10973817, Example 71 | ...)
Affinity DataIC50: >100nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent