BDBM402015 5-[[5-[2-methoxy-4-[[(3R)-3-methoxypyrrolidin-1-yl]methyl]phenyl]-1H-pyrazol-3-yl]amino]pyrazine-2-carbonitrilehydrochloride::US10010547, Example 125::US10973817, Example 125
SMILES CO[C@@H]1CCN(Cc2ccc(-c3cc(Nc4cnc(cn4)C#N)n[nH]3)c(OC)c2)C1
InChI Key InChIKey=AJRQNWYIKQZBFI-MRXNPFEDSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 402015
Affinity DataIC50: 0.280nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
Affinity DataIC50: 0.280nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair