BDBM402038 5-[[5-[4-[(1-isopropyl-4-piperidyl)methyl-methyl-amino]-2-methoxy-phenyl]-1H-pyrazol-3-yl]amino]pyrazine-2-carbonitrilehydrochloride::US10010547, Example 148::US10973817, Example 148
SMILES COc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)N(C)CC1CCN(CC1)C(C)C
InChI Key InChIKey=AEPNHFGXBNBGTO-UHFFFAOYSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 402038
Affinity DataIC50: 0.0310nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0310nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair