BDBM402038 5-[[5-[4-[(1-isopropyl-4-piperidyl)methyl-methyl-amino]-2-methoxy-phenyl]-1H-pyrazol-3-yl]amino]pyrazine-2-carbonitrilehydrochloride::US10010547, Example 148::US10973817, Example 148

SMILES COc1cc(ccc1-c1cc(Nc2cnc(cn2)C#N)n[nH]1)N(C)CC1CCN(CC1)C(C)C

InChI Key InChIKey=AEPNHFGXBNBGTO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 402038   

TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM402038(5-[[5-[4-[(1-isopropyl-4-piperidyl)methyl-methyl-a...)
Affinity DataIC50:  0.0310nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM402038(5-[[5-[4-[(1-isopropyl-4-piperidyl)methyl-methyl-a...)
Affinity DataIC50:  0.0310nMAssay Description:Chk-1 Kinase Inhibiting ActivityThe compounds of the invention were tested for activity against Chk-1 kinase using the materials and protocols set ou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent