BDBM402321 6-(3-(2-chloro-4-((5- cyclopropyl-3-(2,6- dichlorophenyl)isoxazol-4- yl)methoxy)phenyl)-3- hydroxyazetidin-1- yl)nicotinic acid::US10329286, Example 2::US11247986, Example 2

SMILES OC1(CN(C1)c1ccc(OC=O)cn1)c1ccc(OCc2c(onc2-c2c(Cl)cccc2Cl)C2CC2)cc1Cl

InChI Key InChIKey=LFVWDVUXUDKRGB-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 402321   

TargetBile acid receptor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM402321(6-(3-(2-chloro-4-((5- cyclopropyl-3-(2,6- dichloro...)
Affinity DataEC50:  2.60nMAssay Description:Expression and purification of the FXR-LBD: An overnight preculture of a transformed E. coli strain was diluted 1:20 in LB-Ampicillin medium and grow...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBile acid receptor [187-472](Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM402321(6-(3-(2-chloro-4-((5- cyclopropyl-3-(2,6- dichloro...)
Affinity DataEC50:  2.60nMAssay Description:Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding mediated activation of FXR was performed as follow...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent