BDBM402575 N-(4-cyanothiophen-3-yl)- 2-(1,4-diazepan-1- yl)pyrrolo[2,1- f][1,2,4]triazine-7- carboxamide trifluoroacetate::US10329295, Example 12

SMILES O=C(Nc1cscc1C#N)c1ccc2cnc(nn12)N1CCCNCC1

InChI Key InChIKey=MOSCEAKEAHUAKV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 402575   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402575(N-(4-cyanothiophen-3-yl)- 2-(1,4-diazepan-1- yl)py...)
Affinity DataIC50:  365nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent