BDBM402740 N-(3-cyano-1-methyl-1H- pyrazol-4-yl)-2-[(1S,4S)- or (1R,4R)-2,5- diazabicyclo[2.2.2]oct-2- yl]pyrrolo[2,1- f][1,2,4]triazine-7- carboxamide trifluoroacetate::US10329295, Example 47

SMILES Cn1cc(NC(=O)c2ccc3cnc(nn23)N2C[C@H]3CC[C@@H]2CN3)c(n1)C#N

InChI Key InChIKey=OPXFFQQCPSTNPD-VXGBXAGGSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 402740   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402740(N-(3-cyano-1-methyl-1H- pyrazol-4-yl)-2-[(1S,4S)- ...)
Affinity DataIC50:  265nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent